I've been using the dvorak layout since 2001. Never really had many problems; all operating systems seem to support it, and coworkers are easily trained in the use of one's preferred keyboard switching UI should they need to use one's PC. Initially some people seemed to act as if this was some kind of fad, one that I'd soon get over, but as the months ground on, and then the years (since 2001 I've worked on and off with many of the same group of people), and my keyboard layout didn't change back, this attitude seemed to die down.
The only technical problem I've had, I think, is that at one point if you were the first person to sign in to a remote system over Remote Desktop, you'd imbue that session with your locale and keyboard layout. No good when I happened to be the first person to log in.
I haven't even found my QWERTY skills atrophying that much; on a non-split or laptop keyboard I can type QWERTY without looking at 75wpm, without too many slips. On a split keyboard, like the ones I prefer to use, if I have to type QWERTY then I do have to look at my hands as I type.
The only technical problem I've had, I think, is that at one point if you were the first person to sign in to a remote system over Remote Desktop, you'd imbue that session with your locale and keyboard layout. No good when I happened to be the first person to log in.
I haven't even found my QWERTY skills atrophying that much; on a non-split or laptop keyboard I can type QWERTY without looking at 75wpm, without too many slips. On a split keyboard, like the ones I prefer to use, if I have to type QWERTY then I do have to look at my hands as I type.