By the way, not very well known but benadryl (OTC antihstamine) and Chlortrimeton (OTC antihstamine) are some of the oldest substances, known to have serotonin and norepinephrine reuptake inhibition features. In fact Prozac was synthesised from benadryl, in attempt to make it more potent antidepressant. Chlorpheniramine was researched by swedish scientist, who won Nobel prize (not sure for what exactly), in 1950-s and was found to have SNRI effects. But I beleive these will never be researched again - it hurts potential profits for Pharma.Who needs month of supply of antidepressant for $10, when you can sell it for 200?