Not without some serious legislative and financial changes - the deck is stacked very much in favor of 'companies' (and generally larger ones at that) than smaller ones, and certainly not in favor of freelancers.
Big in number of employees or capital? I wonder if you could have a fully outsourced company, where a mesh of algorithms would allocate capital to hire freelances, adquire resources, etc. I suppose it'd be hard to create new products and services, but you could always automate the acquisition of startups ;)
