Follow up in 2015 with essentially the same conclusions:

"Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2 Synthesis"

https://accp1.onlinelibrary.wiley.com/doi/abs/10.1002/jcph.6...

Thanks for sharing this!

I got prescribed 30 days of low-dose aspirin after my hip replacement to prevent clotting. 81mg. At least I didn't have side effects, the other anti-inflammatory made my brain foggy.

What's the benefit of taking aspirin regularly anyways?

It’s supposed to help reduce clotting, and thus help a bit to prevent a heart attack, at least that’s what I understood from my heart doctor. Generally you’d take the 81mg “baby aspirins” for this, not a full adult dose.

or in this case one fizzy tablet every three days? Are tehre people doing this long term? Doesn't sound all that compatible with colon.

After a heart procedure my doctor told me to take the 81mg daily for the rest of my life. It’s been about 20 years now, with no side effects that I know of.

This could mitigate side effects (stomach ulcers, bleeding) while retaining most of the benefits.

Some research suggests the stomach bleed risk comes from the platelet inhibition itself, which would mean you can't have the good effect without the bad.

Hang on, the 2015 study suggests otherwise.

Daily dose suppressed PGE2 while 3-daily dose didn't.

> Since PGE2 is involved in gastric healing, we understand that this new approach could be safer and as efficient as the standard daily therapy on a long-term basis.

So in one case you get triple the daily dose (325 mg vs 81mg) every three days. I'm not sure how that would mitigate side effects?

From the summary, only small difference between 81mg daily vs 81mg every 3 days, i.e 87% benefit at 33% averaged dosage.

  325mg every third day: 86% inhibition
  81mg per day:          85% inhibition
  81mg every third day:  74% inhibition

I would recommend asking your medical practitioner about enteric-coated forms.

I am nearly nine months into NSAID gastritis from only a week of daily 75mg soluble Aspirin.

I have had more painful acute illnesses in the past, but the grind of a long-term illness is new to me and it has been absolutely terrible.

Is there a good heuristic now for which things on nih.gov.or cdc.gov are real science?

This is a paper published from 2001 with no bearing on the current political climate.

The concern is whether the file is unaltered from its original 2001 release.

Source PDF with identical summary text: https://journals.sagepub.com/doi/epdf/10.1177/10760296010070...