I’d say the V-2 as the first missile. The V-1 would be more like a drone.

That part is misleading and not present in the original article (headline or body).

Just thinking about the comparison with modern warfare drones. I wonder if the population at large is actually safer due to more accurate (or even any) targeting?

That's fine but don't editorialize titles to add your own question/commentary which is what the comments are for.