Tell that to the companies trying to push MIPS SOC's for Android smartphones. If it isn't ARM, they tell them to get lost. Likewise, for x86 + Windows. As ARM and Intel themselves say, being able to leverage the ecosystem of existing code, tools, talent, and so on is a huge differentiator. ARM on mobile (esp iOS & Android) has a massive ecosystem and many tool vendors whereas RISC-V or Wirth's CPU's don't have jack. So, manufacturers explicitly require ARM for high-end smartphones and SOC makers default on it despite ridiculous licensing cost.
Note: Areas like embedded in general with smaller, custom jobs don't worry about ISA's as much. Plenty of ARM, MIPS, PPC, x86, SPARC, Super-H, 16bits, 8bits... you name it. Much more fun space to be a programmer if you get to pick the cpu/board. :)
I'm in the GPU business. Here, ISA compatibility does not even exist and nobody cares. As long as you own an entire toolchain - a GLES/OpenCL driver, or, as in this case, an Oberon OS and a compiler - nobody gives a tiniest bit of crap about the underlying ISA.
So, I do not see any reason for the Oberon machine to rely on any "standard" ISA. It can even be compiled into some kind of a NISC, and nobody would notice any difference.
Oh I agree about Oberon and GPU's. My argument is for mainstream market for software in desktops and mobile. The ISA usually does matter.
Now, if we're talking GPU's, the effective ISA would be DirectX, OpenGL, OpenCL, etc. They're the standards that software and tooling target. So, does you product get by with not supporting any of those? Or do you have to comply with the your niche's standard interfaces and ecosystems, too?